Low back pain is a common musculoskeletal disorder affecting 80% of people at some point in their lives. It is the most common cause of job-related disability, a leading contributor to missed work, and the second most common neurological ailment. Cupping is used in the treatment and cure of a broad range of conditions; general physical as back pain and mental well-being. This study aimed to evaluate effectiveness of cupping therapy (Al-Hijama) on management of persistent non-specific lower back pain and client disability. Subjects & Methods, The study was conducted at Islamic Al-Hijama Centre – Yanbu City – Al Madinah Al Munawarah – Kingdom of Saudi Arabia. Thirty adult clients diagnosed with nonspecific low back pain were enrolled in the study with inclusive and exclusive criteria; Data collection tools: Client assessment sheet; American Pain Society Client Outcome Questionnaire and Oswestry Low Back Pain Disability Questionnaire, Results, sample included (86.7%) males used wet cupping therapy (76.7%), there were highly statistical significant for assessment of pain pre and post cupping therapy; and client’s ability to manage everyday life. Conclusion, cupping therapy is effective in relieving persistent non- specific lower back pain and client disability; no adverse effects were reported from subjects after the treatment. It is recommended that using cupping therapy for enhance disability and decrease pain of lower back pain.